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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sanchez, Dikember | CL | Biloxi Shuckers | 21 | 02/20/2004 | Caracas | VEN | Right | Right | 5' 11" | 160 lbs | - |
| Sanders, Will | SP | Knoxville Smokies | 22 | 03/30/2002 | Atlanta | USA | Left | Right | 6' 6" | 230 lbs | - |
| Santana, Tyler | RP | Knoxville Smokies | 26 | 05/13/1998 | Miami Springs | USA | Right | Right | 6' 1" | 205 lbs | - |
| Santy, Marino | RP | Knoxville Smokies | 23 | 03/04/2002 | Santo Domingo | DOM | Left | Left | 5' 11" | 170 lbs | - |
| Scalzo Jr., Frankie | RP | Knoxville Smokies | 25 | 11/25/1999 | Vista | USA | Right | Right | 6' 3" | 190 lbs | - |
| Schlaffer, Tyler | RP | Knoxville Smokies | 23 | 05/24/2001 | Homewood | USA | Right | Right | 6' 1" | 180 lbs | - |
| Schomberg, Will | RP | Pensacola Blue Wahoos | 24 | 01/30/2001 | Clemmons | USA | Right | Right | 5' 10" | 190 lbs | - |
| Seabold, Connor | RP | Montgomery Biscuits | 29 | 01/24/1996 | Laguna Hills | USA | Right | Right | 6' 2" | 190 lbs | - |
| Sears, Brett | RP | Columbus Clingstones | 24 | 05/02/2000 | Harlan | USA | Right | Right | 6' 1" | 200 lbs | - |
| Serwinowski, Adam | SP | Chattanooga Lookouts | 20 | 06/07/2004 | Taylors | USA | Left | Left | 6' 5" | 190 lbs | - |
| Shade, Colby | LF | Pensacola Blue Wahoos | 23 | 08/18/2001 | Windsor | USA | Right | Right | 6' 1" | 205 lbs | - |
| Shafer, Jacob | SP | Columbus Clingstones | 22 | 04/30/2002 | High Point | USA | Right | Right | 6' 8" | 240 lbs | - |
| Sikkema, T.J. | RP | Chattanooga Lookouts | 26 | 07/25/1998 | DeWitt | USA | Left | Left | 6' 0" | 220 lbs | - |
| Sikorski, Easton | RP | Chattanooga Lookouts | 25 | 01/12/2000 | Fraser | USA | Right | Right | 6' 0" | 210 lbs | - |
| Simmons, Dylan | RP | Chattanooga Lookouts | 23 | 12/31/2001 | Jacksonville | USA | Right | Right | 6' 3" | 225 lbs | - |
| Smelley, Colby | C | Birmingham Barons | 24 | 03/15/2000 | Tuscaloosa | USA | Right | Right | 6' 1" | 190 lbs | - |
| Smith, Aidan | LF | Montgomery Biscuits | 20 | 07/23/2004 | Lucas | USA | Right | Right | 6' 3" | 190 lbs | - |
| Smith, Hagen | SP | Birmingham Barons | 21 | 08/19/2003 | Bullard | USA | Left | Left | 6' 3" | 225 lbs | - |
| Smith, Jake | RP | Rocket City Trash Pandas | 25 | 10/04/1999 | Chapel Hill | USA | Right | Right | 6' 4" | 190 lbs | - |
| Snelling, Robby | SP | Pensacola Blue Wahoos | 21 | 12/19/2003 | Reno | USA | Right | Left | 6' 3" | 210 lbs | - |
| Snyder, Michael | 1B | Pensacola Blue Wahoos | 24 | 09/16/2000 | Los Angeles | USA | Right | Right | 6' 3" | 230 lbs | - |
| Spain, Garrett | LF | Biloxi Shuckers | 24 | 09/21/2000 | Clarksville | USA | Left | Right | 5' 11" | 180 lbs | - |
| Stanavich, Dale | RP | Pensacola Blue Wahoos | 25 | 06/23/1999 | Amsterdam | USA | Left | Left | 5' 11" | 175 lbs | - |
| Stevens, Chad | 3B | Rocket City Trash Pandas | 26 | 02/03/1999 | Fox Island | USA | Right | Right | 6' 3" | 215 lbs | - |
| Stevens, Tristan | RP | Pensacola Blue Wahoos | 27 | 12/08/1997 | Springfield | USA | Right | Right | 6' 2" | 200 lbs | - |
| Stewart, Sal | 3B | Chattanooga Lookouts | 21 | 12/07/2003 | Miami | USA | Right | Right | 6' 3" | 215 lbs | - |
| Stovall, Hunter | 2B | Montgomery Biscuits | 28 | 09/05/1996 | Pelham | USA | Right | Right | 5' 6" | 170 lbs | - |
