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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Saathoff, Allan | RP | Everett AquaSox | 25 | 09/18/1999 | Ridgely | USA | Right | Right | 6' 1" | 210 lbs | - |
| Sanchez, JJ | RP | Vancouver Canadians | 25 | 09/08/1999 | Los Fresnos | USA | Left | Left | 5' 11" | 185 lbs | - |
| Santa Cruz de Oviedo, Anthony | 1B | Tri-City Dust Devils | 17 | 03/15/2007 | Matanzas | CUB | Left | Left | 6' 3" | 180 lbs | - |
| Santana, Ruben | 3B | Hillsboro Hops | 20 | 02/16/2005 | El Seibo | DOM | Right | Right | 6' 0" | 190 lbs | - |
| Schaeffer, Brandon | SP | Everett AquaSox | 25 | 06/05/1999 | Auburn | USA | Left | Left | 6' 2" | 195 lbs | - |
| Scull, Anthony | CF | Tri-City Dust Devils | 21 | 01/26/2004 | Havana | CUB | Left | Left | 6' 0" | 165 lbs | - |
| Semmel, Montana | RP | Free Agent | 23 | 01/01/2002 | Stamford | USA | Right | Right | 6' 4" | 225 lbs | - |
| Sharp, Jacob | C | Vancouver Canadians | 23 | 09/15/2001 | La Mirada | USA | Right | Right | 5' 7" | 180 lbs | - |
| Shawver, Evan | RP | Spokane Indians | 25 | 09/11/1999 | Amherst | USA | Right | Left | 6' 0" | 170 lbs | - |
| Shen, Chia-Shi | SP | Everett AquaSox | 21 | 12/03/2003 | Puli | TPE | Right | Right | 6' 3" | 185 lbs | - |
| Simon, Liam | SP | Eugene Emeralds | 24 | 10/16/2000 | Princeton | USA | Right | Right | 6' 4" | 220 lbs | - |
| Sims, Landon | CL | Hillsboro Hops | 24 | 01/03/2001 | Cumming | USA | Right | Right | 6' 2" | 225 lbs | - |
| Sosa, Gabriel | RP | Free Agent | 23 | 04/17/2001 | San Cristóbal | DOM | Right | Right | 6' 2" | 185 lbs | - |
| Southard, Jared | RP | Tri-City Dust Devils | 24 | 10/04/2000 | Leander | USA | Right | Right | 6' 2" | 220 lbs | - |
| St. Laurent, Austin | RF | Everett AquaSox | 22 | 07/13/2002 | Elon | USA | Right | Right | 6' 0" | 190 lbs | - |
| Stanifer, Gage | SP | Vancouver Canadians | 21 | 11/18/2003 | Carmel | USA | Right | Right | 6' 3" | 180 lbs | - |
| Stone, Alex | C | Vancouver Canadians | 23 | 11/03/2001 | Andover | USA | Right | Right | 6' 5" | 235 lbs | - |
| Strickland, Austin | CL | Eugene Emeralds | 22 | 05/31/2002 | Winchester | USA | Right | Right | 6' 2" | 210 lbs | - |
| Stryffeler, Michael | RP | Eugene Emeralds | 28 | 05/22/1996 | Northfield | USA | Right | Right | 6' 2" | 210 lbs | - |
| Suarez, Alexander | LF | Eugene Emeralds | 23 | 12/20/2001 | Valera | VEN | Right | Right | 6' 2" | 160 lbs | - |
| Suisbel, Luis | 1B | Everett AquaSox | 21 | 05/23/2003 | Valencia | VEN | Switch | Right | 6' 1" | 190 lbs | - |
