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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Salazar, Grabiel | RP | Aberdeen Ironbirds | 24 | 02/19/2001 | Punta de Piedras | VEN | Right | Right | 6' 0" | 165 lbs | - |
| Sanchez, Luis | 3B | Rome Emperors | 21 | 01/16/2004 | Panama | PAN | Right | Right | 5' 9" | 165 lbs | - |
| Sanchez, Luis | CL | Aberdeen Ironbirds | 22 | 03/04/2003 | San Francisco de Macorís | DOM | Right | Right | 6' 0" | 170 lbs | - |
| Sanchez, Wilber | 2B | Free Agent | 23 | 02/21/2002 | Caracas | VEN | Right | Right | 5' 10" | 160 lbs | - |
| Sanchez, Wilmy | RP | Asheville Tourists | 21 | 12/17/2003 | Santiago | DOM | Right | Right | 5' 9" | 210 lbs | - |
| Santana, Adrian | SS | Bowling Green Hot Rods | 19 | 07/18/2005 | Miami | USA | Switch | Right | 5' 11" | 160 lbs | - |
| Santos, Miguel | 2B | Winston-Salem Dash | 24 | 03/12/2001 | Burleson | USA | Right | Right | 5' 10" | 170 lbs | - |
| Santucci, Jonathan | SP | Brooklyn Cyclones | 22 | 12/28/2002 | Leominster | USA | Left | Left | 6' 2" | 205 lbs | - |
| Saucke II, Casey | RF | Winston-Salem Dash | 21 | 07/24/2003 | Rochester | USA | Right | Right | 6' 3" | 210 lbs | - |
| Scarborough, Caden | SP | Hub City Spartanburgers | 19 | 04/01/2005 | St. Cloud | USA | Right | Right | 6' 5" | 185 lbs | - |
| Schanaman, Shay | RP | Rome Emperors | 25 | 08/12/1999 | Grand Island | USA | Right | Right | 6' 0" | 205 lbs | - |
| Schiavone, Jason | C | Asheville Tourists | 21 | 03/19/2003 | Laytonsville | USA | Right | Right | 6' 3" | 205 lbs | - |
| Schultz, Thomas | RP | Wilmington Blue Rocks | 25 | 08/03/1999 | Mt. Carmel | USA | Right | Right | 6' 6" | 245 lbs | - |
| Serrano, Eli | 1B | Brooklyn Cyclones | 21 | 05/01/2003 | Fuquay-Varina | USA | Left | Left | 6' 5" | 210 lbs | - |
| Serrano, Florencio | RP | Free Agent | 25 | 02/23/2000 | Corpus Christi | USA | Right | Right | 6' 2" | 210 lbs | - |
| Severino, Jhonny | 3B | Greensboro Grasshoppers | 20 | 11/08/2004 | Santo Domingo | DOM | Right | Right | 6' 3" | 185 lbs | - |
| Sharp, Reese | RP | Aberdeen Ironbirds | 24 | 08/07/2000 | Noblesville | USA | Right | Right | 6' 3" | 205 lbs | - |
| Sherwin, Anthony | 2B | Asheville Tourists | 22 | 06/03/2002 | Maumee | USA | Left | Right | 5' 10" | 190 lbs | - |
| Shojinaga, Kodey | C | Jersey Shore BlueClaws | 22 | 02/22/2003 | Honolulu | USA | Right | Right | 5' 10" | 190 lbs | - |
| Silva, Daniel | C | Brooklyn Cyclones | 20 | 01/12/2005 | Caracas | VEN | Switch | Right | 6' 2" | 200 lbs | - |
| Silva, William | RP | Rome Emperors | 23 | 08/02/2001 | Miami | USA | Right | Right | 6' 0" | 185 lbs | - |
| Simas, Kohl | SP | Winston-Salem Dash | 25 | 12/22/1999 | Fresno | USA | Right | Right | 6' 1" | 190 lbs | - |
| Simeon, Victor | RP | Free Agent | 24 | 12/04/2000 | San Pedro de Macorís | DOM | Right | Right | 6' 2" | 160 lbs | - |
| Simon, Ben | RP | Brooklyn Cyclones | 22 | 03/22/2002 | Hightstown | USA | Left | Right | 5' 11" | 195 lbs | - |
| Simpson, Jared | RP | Wilmington Blue Rocks | 24 | 06/28/2000 | Clinton | USA | Left | Left | 6' 4" | 205 lbs | - |
| Sinnard, Luke | SP | Rome Emperors | 22 | 10/21/2002 | Hendersonville | USA | Right | Right | 6' 8" | 250 lbs | - |
| Smith, Adam | RP | Greenville Drive | 24 | 05/09/2000 | West Chester | USA | Right | Right | 6' 2" | 200 lbs | - |
| Smith, Austin | RP | Rome Emperors | 25 | 06/22/1999 | Cedar Park | USA | Right | Right | 6' 4" | 210 lbs | - |
| Smith, Cade | SP | Hudson Valley Renegades | 22 | 04/09/2002 | Southaven | USA | Left | Right | 6' 1" | 190 lbs | - |
| Smith, Parker | SP | Asheville Tourists | 22 | 03/05/2003 | Bellaire | USA | Right | Right | 6' 4" | 230 lbs | - |
| Snelsire, Hayden | RP | Bowling Green Hot Rods | 24 | 01/16/2001 | Berlin | USA | Right | Right | 6' 3" | 205 lbs | - |
| Snyder, Jack | RP | Bowling Green Hot Rods | 26 | 08/04/1998 | Chicago | USA | Right | Right | 6' 2" | 205 lbs | - |
| Sosa, Thomas | RF | Aberdeen Ironbirds | 20 | 01/18/2005 | Mella | DOM | Left | Left | 6' 1" | 160 lbs | - |
| Spikerman, John | RF | Jersey Shore BlueClaws | 21 | 04/02/2003 | Montgomery | USA | Switch | Right | 6' 0" | 180 lbs | - |
| Spikes, Ryan | LF | Bowling Green Hot Rods | 22 | 03/13/2003 | Covington | USA | Right | Right | 5' 9" | 180 lbs | - |
| Sprinkle, Jordan | 2B | Winston-Salem Dash | 24 | 03/06/2001 | Indio | USA | Right | Right | 5' 10" | 170 lbs | - |
| Stark, Cal | C | Hub City Spartanburgers | 22 | 07/27/2002 | Knoxville | USA | Right | Right | 6' 2" | 205 lbs | - |
| Stebens, Isaac | RP | Greenville Drive | 23 | 12/05/2001 | Stillwater | USA | Right | Right | 6' 0" | 195 lbs | - |
| Stehly, Murphy | 3B | Wilmington Blue Rocks | 26 | 09/27/1998 | Carlsbad | USA | Right | Right | 5' 10" | 205 lbs | - |
| Steward, Casey | SP | Jersey Shore BlueClaws | 23 | 08/02/2001 | Wichita | USA | Right | Right | 6' 5" | 260 lbs | - |
| Sullivan, Joseph | 1B | Asheville Tourists | 22 | 07/01/2002 | Birmingham | USA | Left | Left | 5' 11" | 200 lbs | - |
| Swiney, Nick | RP | Free Agent | 26 | 02/12/1999 | Raleigh | USA | Right | Left | 6' 3" | 180 lbs | - |
